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Effects of dietary intervention on diet inflammatory index and asthma characteristics in obese asthmatic individuals: Randomized controlled trial
1Department of Nutrition and Diet, Ankara University, Ankara, Turkey
2Department of Immunology and Allergy, Ankara University Medical Faculty, Ankara, Turkey
3Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Eurasian Journal of Pulmonology 2021; 23(3): 145-151 DOI: 10.4103/ejop.ejop_130_20
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BACKGROUND AND AIM: Inflammatory factors are very important in the emergence of asthma. In recent years, the inflammatory response caused by diet has also been associated with asthma. In this study, we evaluated the association between the Dietary Inflammatory Index (DII®), weight loss, and asthma characteristics.
METHODS: Obese asthmatic individuals (n = 55) were randomized into the diet (n = 29) or control groups (n = 26) for 10 weeks. The anthropometric measurements, nutrition consumption records (past 24 h), pulmonary function tests DII® were recorded and compared between groups.
RESULTS: After intervention, the DII changes of the individuals in the diet group showed a negative correlation with the changes in forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), mean expiratory flow rate (MEF25–75), asthma control (ACT) and asthma quality of life questionnaire (AQLQ) scores (all P < 0.05). DII changes in the diet group showed a positive significant partial correlations (i.e. controlling for important confounders) with changes in body weight (r = 0.527; 95% confidence interval [CI]: 0.211, 0.725), FEV1, (r = −0.486; 95% CI: −0.695, −0.249), and FVC (r = −0.459; 95% CI: −0.688, −0.162). FEV1, peak expiratory flow (PEF), MEF25–75, MEF25 and ACT scores decreased with increasing DII from tertile 1 to tertile 3 (P <0.05).
CONCLUSIONS: Weight loss through diet intervention and decrease in the inflammatory load of diet increase pulmonary function and improve asthma control.