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The effect of blood parameters on the frequency of thromboembolic events in Covid-19 patients
1Deparment of Chest Diseases, Kocaeli City Hospital, Kocaeli, Türkiye
2Deparment of Cardiovascular Surgery, Kocaeli City Hospital, Kocaeli, Türkiye
3Department of Infectious Diseases and Clinical Microbiology, Bulanık State Hospital, Muş, Türkiye
4Department of Emergency, Gebze Century Hospital, Kocaeli, Türkiye
5Emergency Department, Kocaeli Academy Hospital, Kocaeli, Türkiye
Eurasian Journal of Pulmonology - DOI: 10.14744/ejp.2024.2003

Abstract


Background and Aim: COVID-19 infection is associated with increased thromboembolic events. The aim of our study was to investigate the frequency of in-hospital thromboembolic events in patients with COVID-19 and to investigate the effect of blood parameters taken at the time of diagnosis on the development of thromboembolic events.

Methods: The demographic data, the frequency of thromboembolic events and the blood parameters at the time of diagnosis of the patients were recorded.

Results: A total of 2323 patients, 1136 women (48.9%) and 1187 men (51.1%) were included in the study.Thromboembolic events were observed in 103 (4.4%) patients during hospitalisation. DVT occurred in 4 patients (0.2%), PTE in 3 patients (0.15%), peripheral arterial disease in 4 patients (0.2%), cerebrovascular event in 17 patients (0.7%), mesenteric ischaemia in 1 patient (0.05%) and MI in 74 patients (3.2%).Thromboembolic events were significantly higher in patients with HT (p=0.03), heart failure (p=0.023), chronic kidney disease (p=0.017) and COPD (p=0.035) compared to those without. The age of patients with thromboembolic events was significantly higher than that of patients without thromboembolic events (p=0.003). Among laboratory parameters, hemoglobin was significantly lower (p=0.002) and mean platelet volume (MPV) was significantly higher (p=0.009) in patients with thromboembolic events. In multiple regression analysis, the risk factors associated with thromboembolic events were age (OR: 0.44, 95% CI: 0.0 - 0.001; p=0.045), hemoglobin (OR: -0.46, 95% CI: -0.09 - 0.00; p=0.036) and MPV (OR: 0.05, 95% CI: 0.001 - 0.015; p=0.018).
Conclusions: Advanced age is a risk factor for thromboembolic events in COVID-19 patients. It is thought that hemoglobin and MPV at admission may also contribute to the prediction of thromboembolic events.