A case of severe eosinophilic asthma who concieved while receiving mepolizumab treatment

Aksu, Kurtuluş; Yağdıran, Melis; Çelik Tuğlu, Hatice; Telli, Onur; Akkale, Özgür; Dindar Çelik, Fatma

doi:10.14744/ejp.2024.1007

Kurtuluş Aksu¹ ,

Melis Yağdıran¹ ,

Hatice Çelik Tuğlu¹ ,

Onur Telli¹ ,

Özgür Akkale¹ ,

Fatma Dindar Çelik¹

¹Division of Immunology and Allergy, Department of Chest Diseases, University of Health Sciences Atatürk Sanatoryum Training and Research Hospital, Ankara, Türkiye

Eurasian Journal of Pulmonology - DOI: 10.14744/ejp.2024.1007

Abstract

A 30-year-old female patient with steroid-dependent severe eosinophilic asthma and chronic eosinophilic pneumonia was successfully treated with mepolizumab for 15 months. When the patient applied to the16th month of mepolizumab treatment, she reported that she had an unplanned pregnancy and was 4 weeks pregnant. Biological treatment was discontinued and the patient was followed up with combination of inhaled corticosteroid (ICS) and long-acting beta agonist (LABA) and oral steroids. The patient had frequent exacerbations during follow-up and was treated appropriately. The patient gave birth to a healthy baby via normal spontaneous vaginal delivery at 39 weeks.

Keywords:  Asthma, Biological treatment, Chronic eosinophilic pneumonia, Mepolizumab, Pregnancy